Assessment of Possible Link Between Uropathogenic Escherichia Coli and Azoospermia in Male Mice

Controversies and debates still prevail in current literature concerning the role of bacterial infection male infertility. A handful studies have discovered a correlation between bacteria azoospermia condition which discharge is utterly devoid spermatozoa. In line with this, present study was designed to evaluate influence Escherichia coli on spermatogenesis. single dose (108 cfu/20ul) uropathogenic causing sperm agglutination administered intratesticularly animals were euthanized Day 7. Various parameters viz. body weight profile, TSI (%), load, spermiogram analysis, histopathological changes evaluated comparison control group PBS. The administration E. led impairment spermatogenesis as evident by absence spermatozoa right side testis revealed examination testes showing altered histology. histology depicted hypospermatogenesis significant alterations tissue architecture no compared group, indicating azoospermia. If injected into testicles, it can colonise there eventually lead male. This research provides new perspectives allude potential explanation uropathogen reduces man’s reproductive vitality causes long-term damage system.